2017 ACEAT

The Annual Conference on Engineering and Applied Science

Nov 6-9 , 2017, Fukuoka, Japan

Keynote Speech


Associate Professor

Institute of Biotechnology,
National Taiwan University,

Topic: Production of Bacterial Cellulose and Its Application in Wound Healing

Summary of Keynote Speech

Bacterial cellulose (BC), produced by microorganisms such as Komagataeibacter xylinus, is used in wound healing applications due to its material properties, including the ability to maintain high-water content and good biocompatibility. Moreover, BC also presents regular network structure (typical crystalline form of cellulose Iα), which provides flexible material property and high strength. Numerous BC dressing studies are being investigated to improve wound healing characteristics through usage of different cultivation systems and surface modification of BC. Development of an ideal wound dressing to efficiently improve wound healing process is an important issue in wound care. The present study aims to cross-link dextran with bacterial cellulose (BC) to form a dextran/BC hydrogel, and to evaluate the performance of dextran-modified BC hydrogel in a mouse model. This is the first report to apply dextran/BC hydrogel as wound dressing. Our results indicated that the modified dressing - dextran/BC hydrogel - appears to contain a high-water content, rigid but flexible material properties, fine cell proliferation with non-cytotoxicity at the cell-based level, and excellent wound healing ability in vivo. The added dextran plays a key role in that it promotes fibroblast cell growth in the proliferation stage and also help skin maturation in the remodeling stage, causing the acceleration of the wound healing process. It is important to note that this is superior to the commercial wound dressings. Human studies are needed to further investigate the applications as a therapy for different types of wounds.


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